SUVmax on 18F-FDG PET/CT and Histopathological Necrosis in Osteosarcoma and Ewing Sarcoma
BioMed Research International, cilt.2026, sa.1, 2026 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2026 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1155/bmri/4420962
- Dergi Adı: BioMed Research International
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Aerospace Database, BIOSIS, CINAHL, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Middle East & Africa Database (ProQuest), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Technology Collection (ProQuest)
- Anahtar Kelimeler: F-18-FDG PET/CT, Ewing sarcoma, osteosarcoma, SUVmax, tumor necrosis percentage
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: This study is aimed at evaluating the relationship between preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) findings and histopathological necrosis rates following chemotherapy in patients diagnosed with osteosarcoma (OST) and Ewing sarcoma (EWS). Methods: Patients diagnosed with OST and EWS between 2017 and 2023 were retrospectively analyzed. Data recorded included preoperative 18F-FDG PET/CT findings, demographic characteristics, histopathological diagnosis, maximum standardized uptake value at diagnosis (SUVmax1), maximum standardized uptake value after neoadjuvant chemotherapy (SUVmax2), the SUVmax change ratio (SUVmax2/SUVmax1 = SCR), and the percentage of tumor necrosis in resected specimens. Results: A total of 49 patients (33 OST and 16 EWS) were included, consisting of 22 females (44.9%) and 27 males (55.1%) with a median age of 12 years (range: 4–20). Median SUVmax1, SUVmax2, and SCR values were 6.8 (0–22.5), 2.5 (0–9.42), and 0.38 (0–1.44), respectively. The median tumor necrosis percentage was 20% (range: 0–100). Stratification according to SUVmax2 (< 2.5 vs. ≥ 2.5) revealed no significant difference in necrosis percentage (p = 0.234). No significant correlation was observed between SCR and necrosis percentage (p = 0.102). However, a significant inverse correlation was found between SUVmax2 and necrosis percentage in the overall cohort (p = 0.040, r = –0.295), which was more pronounced in OST patients (p = 0.014, r = –0.426). Conclusion: 18F-FDG PET/CT is a valuable imaging modality for predicting histopathological response in solid tumors. Consistent with adult studies, our findings demonstrate that post-NACT FDG uptake is inversely correlated with tumor necrosis percentage, particularly in pediatric OST patients. These results highlight the potential of 18F-FDG PET/CT as a noninvasive prognostic tool to assist in early identification of poor responders.