The spitzer-weinstein syndrome: One form of type IV renal tubular acidosis and its response to indapamide: A case report Spitzer-weinstein sendromu: Tip 4 renal tubuler asidozun bir formu ve i̇ndapamide cevabi: Bir olgu sunumu
Turkish Nephrology, Dialysis and Transplantation Journal, cilt.21, sa.2, ss.201-204, 2012 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 2
- Basım Tarihi: 2012
- Doi Numarası: 10.5262/tndt.2012.1002.20
- Dergi Adı: Turkish Nephrology, Dialysis and Transplantation Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.201-204
- Anahtar Kelimeler: Spitzer-Weinstein syndrome, Persistent hyperkalemia, Metabolic acidosis, Indapamide
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Spitzer-Weinstein is rare disorder characterized by thiazide responsive hyperkalemia and normal anion gap metabolic acidosis, similar to Gordon syndrome.The hyperfunction of thiazide-sensitive Na-Cl cotransporter (TSC) is the main pathophysiological mechanism. We present a 21-year-old male with normal blood pressure, persistently elevated serum potassium, and metabolic asidosis. The diagnosis of Spitzer-Weinstein syndrome was made by clinical pictures and thiazide test. After using 1.5 mg indapamide from a group of thiazide diuretics, his serum potassium decreased from 6.68 mmol/L to 3.54 mmol/L and the daily urine potassium excretion increased from 13.2 mmol to 34.1 mmol. This patient then took indapamide 1.5 mg daily. The persistent hyperkalemia and metabolic acidosis were corrected. Thiazide, a powerful inhibitor of TSC, proved to be a useful tool for the diagnosis and treatment of Spitzer-Weinstein syndrome.