Isotretinoin does not alter VEGF-A and VEGF-C levels: do retinoids behave differently in dose-dependent and/or in vivo/in vitro conditions?
Cutaneous and Ocular Toxicology, cilt.39, sa.4, ss.328-331, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 4
- Basım Tarihi: 2020
- Doi Numarası: 10.1080/15569527.2020.1802743
- Dergi Adı: Cutaneous and Ocular Toxicology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Environment Index, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.328-331
- Anahtar Kelimeler: Isotretinoin, 13-cis-retinoic acid, retinoids, VEGF-A, VEGF-C, growth factor
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: It is seen that various forms of retinoids have different results on VEGF-A and VEGF-C levels when tested at different dosages, in different diseases and under different conditions such as in vivo or in vitro. Objective: To evaluate the effects of isotretinoin on VEGF-A and VEGF-C levels in humans. Methods: Blood samples at the third month of the patient group and blood samples of the control group were compared in terms of VEGF-A and VEGF-C concentrations. Results: No statistically significant difference was observed between the patient group and the control group in terms of VEGF-A and VEGF-C levels. Limitations: Most of the patients discontinued treatment and could not reach the required number, the study was converted to case–control. Conclusions: We think that 0.5 mg/kg/day isotretinoin has no effect on blood concentrations of VEGF-A and VEGF-C in humans. Therefore, there is a need for studies using isotretinoin in different doses and durations in humans in order to better evaluate its effects.