Vasodilating mechanisms of testosterone
Experimental and Clinical Endocrinology and Diabetes, cilt.115, sa.1, ss.1-6, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 115 Sayı: 1
- Basım Tarihi: 2007
- Doi Numarası: 10.1055/s-2007-949657
- Dergi Adı: Experimental and Clinical Endocrinology and Diabetes
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1-6
- Anahtar Kelimeler: testosterone, vasodilation, vascular smooth muscle, nongenomic effects
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The increased incidence of cardiovascular disease in man compared with premenopausal women suggests an unfavourable effect of male sex hormone testosterone on the cardiovascular system. However, numerous clinical and epidemiological studies reported a controversial relationship between testosterone and cardiovascular disease. Furthermore, an increasing amount of evidence indicate that testosterone can exert acute vasorelaxing effects, via non-genomic mechanisms. These effects involve primarily the vascular smooth muscle, without requiring the presence of endothelium, although an endothelial contribution is apparent in some studies. To date, the mechanism behind the vasodilatory action of testosterone is still under debate and might be through either activation of K+ channels or blockade of Ca2+ channels in vascular muscle cells. The purpose of this article is to review the evidence regarding the vasodilating effect of testosterone as well as its mechanism of action. © J.A. Barth Verlag in Georg Thieme Verlag KG Stuttgart.