Does the addition of oral dydrogesterone to vaginal progesterone gel in luteal phase support affect IVF-ICSI results?
Kuwait Medical Journal, cilt.57, sa.1, ss.22-27, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 57 Sayı: 1
- Basım Tarihi: 2025
- Dergi Adı: Kuwait Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Sayfa Sayıları: ss.22-27
- Anahtar Kelimeler: infertility, intracytoplasmic sperm injection, in vitro fertilization, luteal phase support, oral dydrogesterone, vaginal progesterone gel
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The aim of this study was to examine the pregnancy outcomes and live birth rates of 90 mg vaginal progesterone gel given alone protocol and 90 mg vaginal progesterone gel given together with 10 mg oral dydrogesterone protocol to provide luteal phase support in women undergoing in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI). Design: A retrospective cohort study Setting: Department of Obstetrics and Gynecology, University of Health Sciences Tepecik Training and Research Hospital, IVF Unit, Izmir, Turkey Subjects: Between January 2018-June 2020, women aged 18-40 years old who underwent ICSI treatment (fresh cycles) were included in the study. Intervention: Clinical and laboratory parameters Main outcome measures: Ongoing pregnancy and live birth rate Results: A total of 291 patients who met our criteria were included in the study. For luteal phase support, 49.1% (n=143) of the patients used 90 mg vaginal progesterone gel alone, 50.9% (n=148) used vaginal progesterone gel combined with 10 mg oral dydrogesterone. Although the vaginal progesterone gel combined with oral dydrogesterone group is numerically higher in terms of pregnancy outcomes, this difference between the groups was not significant in terms of pregnancy per started cycle (27.9% vs 35.1%), ongoing pregnancy per started cycle (17.4% vs. 25.6%), ongoing pregnancy per embryo transfer (14.4% vs 19.5%) and live birth per embryo transfer (13.2% vs 18%). Conclusions: In this study, it was found that adding short-term oral dydrogesterone to the vaginal progesterone gel for luteal phase support did not significantly affect pregnancy outcomes.