Nicotinamide Riboside, an NAD precursor and supplement, reduces liver damage caused by sepsis La nicotinamida ribósido, un precursor y suplemento de NAD, reduce el daño hepático causado por la sepsis
Revista Cientifica de la Facultad de Veterinaria, cilt.36, sa.2, ss.1-7, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 36 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.52973/rcfcv-e362849
- Dergi Adı: Revista Cientifica de la Facultad de Veterinaria
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Directory of Open Access Journals
- Sayfa Sayıları: ss.1-7
- Anahtar Kelimeler: Liver injury, oxidative stress, nicotinamide riboside, sepsis, liver histopathology
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Sepsis leads to liver failure and eventually death. The supplement nicotinamide riboside is an antioxidant and nicotinamide adenine dinucleotide precursor. This study aimed to evaluate the therapeutic effect effect of nicotinamide riboside on liver injury in a rat sepsis model induced by cecal ligation and perforation. 21 rats were divided into 3 groups: control, sepsis and sepsis+ nicotinamide riboside group. Cecal ligation and perforation applied to sepsis and sepsis + nicotinamide riboside groups. Nicotinamide riboside applied to sepsis + nicotinamide riboside group orally (200 mg·kg-1) 1 hour (h) before and 12 h after cecal ligation and perforation. 24 h after cecal ligation and perforation, rats sacrified. Histopathological and biochemical parameters were analyzed. Nicotinamide riboside treatment resulted in a decrease in high levels of aspartate and alanine aminotransferases, creatine, and ceruloplasmin. Serum albumin, calcium, and amylase levels were decreased in sepsis group and increased in sepsis + nicotinamide riboside group (P<0.05). However, no significant differences of uric acid, sodium, magnesium and chloride levels were seen between the groups. The liver structrure that injured because of sepsis were ameliorated histologically. Superoxide dismutase levels were low in sepsis group but elevated in sepsis + nicotinamide riboside group (P<0.05). Malondialdehyde levels were high in sepsis group but elevated in sepsis + nicotinamide riboside group (P<0.05). Nicotinamide riboside mitigated liver tissue damage in septic rats. It corrected the impaired oxidant-antioxidant balance and some serum parameters. This might be evidence of the ameliorative effect of nicotinamide riboside in liver. Nonetheless, new investigations should be held in the future to understand deeply the mechanism.