Effects of adenosine on the duration of monophasic action potential recorded from human right ventricular endocardium
European Journal of Cardiac Pacing and Electrophysiology, cilt.6, sa.4, ss.204-207, 1996 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6 Sayı: 4
- Basım Tarihi: 1996
- Dergi Adı: European Journal of Cardiac Pacing and Electrophysiology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.204-207
- Anahtar Kelimeler: Adenosine, Catecholamines, Isoprenaline, Monophasic action potential
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Adenosine is an endogenous nucleoside which has been shown to antagonise the stimulatory effects of catecholamines in cardiac tissue of animal species. But, there is lack of data concerning whether adenosine modifies the actions of catecholamines on human ventricular myocardium. In the present study, we investigated the effects of adenosine and isoprenaline (isoproterenol) on the duration of monophasic action potential (MAP) recorded from human right ventricular endocardium. A special catheter, for both pacing and MAP recording, was placed at the right ventricular apex in 8 subjects (mean age 29.3 ± 2.3, 2 male, 6 female). MAP duration was determined at 90% repolarisation (APD90). Baseline APD90 was measured at the end of a 2 minute pacing period at a cycle length of 400 ms. APD90 measurements were repeated after 20 mg of intravenous adenosine administration, during isoprenaline infusion and again after adenosine administration during isoprenaline infusion. Adenosine did not change APD90 duration when compared with baseline (230.0 ± 8.2 vs 229.4 ± 7.7) (p > 0.05). Isoprenaline infusion slightly decreased APD90 (229.4 e 7.7 vs 219.4 ± 7.8) (p > 0.05). Repeat dose of adenosine during isoprenaline infusion did not lead to any significant change in APD90 values (219.4 ± 7.8 vs 216.9 ± 6.7) (p > 0.05). We conclude that, single bolus dose of adenosine does not significantly influence the duration of MAP recorded under basal conditions and after catecholamines in human right ventricular myocardium.