Does the Use of Rocuronium-Sugammadex Instead of Succinylcholine in Electroconvulsive Therapy Affect Seizure Duration?

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Oflezer C., Atay Ö., Kaşdoğan Z. E., Özakay G., İPEKÇİOĞLU D., Bahadır H.

Psychiatry Investigation, cilt.19, sa.10, ss.824-831, 2022 (SCI-Expanded, SSCI, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 10
  • Basım Tarihi: 2022
  • Doi Numarası: 10.30773/pi.2022.0123
  • Dergi Adı: Psychiatry Investigation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, EMBASE
  • Sayfa Sayıları: ss.824-831
  • Anahtar Kelimeler: Electroconvulsive therapy, Rocuronium, Sugammadex, Succinylcholine, Seizure
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objective We compared retrospectively the seizure variables of electroconvulsive therapy (ECT) patients after administration of ro-curonium-sugammadex or succinylcholine as a muscle relaxant with propofol anesthesia. Methods The sample comprised 134 ECT patients. The mean age was 33.6±10.48 years. Anesthesia induction was provided with pro-pofol one mg kg-intravenously (IV) followed by succinylcholine 0.5 mg kg-1 IV (n=68) (Group S) or rocuronium 0.3 mg kg-1 IV (n=66) (Group R). For patients who were given rocuronium, reversal of the residual neuromuscular block was accomplished with sugammadex (1.5 mg kg-1 IV). First session seizure variables were compared between the two groups. We also presented the clinical outcome with Clinical Global Impression-Improvement (CGI-I) and overall adverse effects. Results EEG seizure durations in Group R (55.09±36.11 s) and Group S (47.00±26.33 s) were comparable and were not significantly different (p=0.432). The clinical efficacy of ECT measured by CGI-I in both groups was comparable (p=0.075). There were no major com-plications or death during or after ECT. Conclusion The results of this study show that the use of rocuronium-sugammadex as a neuromuscular blocker instead of succinylcho-line during ECT with propofol anesthesia produces similar results in terms of seizure variables and clinical outcomes.