Electrochemical and Theoretical Investigations on the Binding of Anticancer Drug Olaparib to Human Serum Albumin

Keciba, Amina; KARADAŞ BAKIRHAN, Nurgül; GÜNDÜZ, MİYASE; Doulache, Merzak; Saidat, Boubakeur; Atici, Esen; ÖZKAN, SİBEL

doi:10.1149/1945-7111/ad590d

Electrochemical and Theoretical Investigations on the Binding of Anticancer Drug Olaparib to Human Serum Albumin

Keciba A., KARADAŞ BAKIRHAN N., GÜNDÜZ M. G., Doulache M., Saidat B., Atici E. B., ...Daha Fazla

Journal of the Electrochemical Society, cilt.171, sa.6, 2024 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 171 Sayı: 6
Basım Tarihi: 2024
Doi Numarası: 10.1149/1945-7111/ad590d
Dergi Adı: Journal of the Electrochemical Society
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: olaparib, human serum albumin, electrochemical methods, interaction, binding study, molecular docking
Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Highlights Electrochemical techniques have been applied to research the interaction between Olaparib and human serum albumin. The formation of a strong singular drug-albumin complex with a binding constant of 1.12 × 105 M-1 has been obtained. Molecular docking studies supported the experimental findings and provided insights into the binding interactions of olaparib with human serum albumin.