Comparison of the effect of ranibizumab and dexamethasone implant on serous retinal detachment in diabetic macular edema Comparaison de l'effet du ranibizumab et de l'implant de dexamethasone sur le décollement séreux rétinien dans l’œdème maculaire diabétique

Demircan A., Ozkaya A., Alkin Z., Kemer B., Yesilkaya C., Demir G.

Journal Francais d'Ophtalmologie, cilt.41, sa.8, ss.733-738, 2018 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 8
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.jfo.2018.03.004
  • Dergi Adı: Journal Francais d'Ophtalmologie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.733-738
  • Anahtar Kelimeler: Diabetic macular edema, Subfoveal neurosensory retinal detachment, Dexamethasone, Ranibizumab
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Purpose: To compare the efficacy of intravitreal ranibizumab (IVR) and intravitreal dexamethasone implant (IDI) on neurosensory retinal detachment (SRD) associated with diabetic macular edema (DME) in the early treatment period. Methods: This was a retrospective, interventional, case-control study. After three monthly loading doses of IVR or an initial IDI injection, the changes in best-corrected visual acuity (BCVA), central macular thickness (CMT) on OCT, and presence and height of SRD were evaluated. Results: The IVR and IDI groups consisted of 101 and 35 eyes, respectively. The mean changes in CMT in the IVR and IDI groups were 204.4 ± 176.6 and 311.4 ± 163, respectively (P < 0.001). The mean changes in SRD height in the IVR and IDI groups were 133.6 ± 92.1 and 168.6 ± 103.9 μm, respectively. The decrease in SRD height was significantly greater in the IDI group than in the IVR group (P = 0.002). The SRD resolved completely in 72.2% and 71.4% of the patients in the IVR and IDI groups, respectively (P = 0.9). Conclusion: The mean reduction in CMT and SRD height was greater in the IDI group than in the IVR group. There was a negative correlation between baseline best-corrected visual acuity (BCVA) and SRD height and also between BCVA and CMT.