Effects of oral isotretinoin therapy on the nasal cavities Efeitos nasais da terapia com isotretinoína oral
Brazilian Journal of Otorhinolaryngology, cilt.86, sa.1, ss.99-104, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 86 Sayı: 1
- Basım Tarihi: 2020
- Doi Numarası: 10.1016/j.bjorl.2018.10.004
- Dergi Adı: Brazilian Journal of Otorhinolaryngology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- Sayfa Sayıları: ss.99-104
- Anahtar Kelimeler: Acne, Isotretinoin, Rhinomanometry, Saccharine test
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Isotretinoin (13 cis-retinoic acid) is the most effective treatment for acne vulgaris and is the only treatment option that can provide either remission or a permanent cure. Objective: The aim of this study was to use both subjective and objective methods to assess the nasal complaints of patients with severe acne who received oral isotretinoin therapy. Methods: Fifty-four subjects were enrolled in the study. All the subjects were assessed with subjective (NOSE and VAS questionnaires) and objective (rhinomanometry and saccharine) tests to determine the severity of their nasal complaints. Results: The mean severity scores (min: 0; max: 100) for nasal dryness/crusting and epistaxis were 0.47 ± 1.48 (0–5); 0.35 ± 1.30 (0–5) at admission, 3.57 ± 4.45 (0–10); 2.26 ± 4.71 (0–20) at the first month, and 4.28 ± 6 (0–20); 2.26 ± 4.71 (0–20) at the third month of the treatment respectively. Total nasal resistance of 0.195 ± 0.079 (0.12–0.56) Pa/cm3/s at admission, 0.21 ± 0.084 (0.12–0.54) Pa/cm3/s at the first month, and 0.216 ± 0.081 (0.14–0.54) Pa/cm3/s at the third month. Conclusion: Oral isotretinoin therapy can cause the complaint of nasal obstruction. In addition, nasal complaints, such as dryness/crusting and epistaxis, significantly increase in patients during the therapy schedule.