A rare outcome induced by metformin intoxication: Severe lactic acidosis and hepatotoxicity
BANTAO Journal, cilt.14, sa.1, ss.45-47, 2016 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 1
- Basım Tarihi: 2016
- Doi Numarası: 10.1515/bj-2016-0011
- Dergi Adı: BANTAO Journal
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.45-47
- Anahtar Kelimeler: Dialysis, Hemofiltration, Lactic acidosis, Metformin intoxication
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Metformin is a widely used oral anti-diabetic agent that decreases insulin resistance. Lactic acidosis rarely develops with this medication. Metformin-induced hepatotoxicity has been rarely reported in the literature. We describe a patient, who presented with lactic acidosis and hepatotoxicity after ingestion of 40 pills of metformin in order to commit suicide. The most important treatment step in patients with metformin-associated lactic acidosis (MALA) is high-volume hemodialysis and hemofiltration.