Trauma scores and neuron-specific enolase, cytokine and c-reactive protein levels as predictors of mortality in patients with blunt head trauma
Journal of International Medical Research, cilt.38, sa.5, ss.1708-1720, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 38 Sayı: 5
- Basım Tarihi: 2010
- Doi Numarası: 10.1177/147323001003800516
- Dergi Adı: Journal of International Medical Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1708-1720
- Anahtar Kelimeler: BLUNT HEAD TRAUMA, NEURON-SPECIFIC ENOLASE, CYTOKINES, C-REACTIVE PROTEIN, GLASGOW COMA SCALE, REVISED TRAUMA SCORE
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
This study evaluated serum neuron specific enolase (NSE), cytokine and high sensitivity C-reactive-protein (hs-CRP) levels, along with the Glasgow Coma Scale (GCS) and Revised Trauma Score (RTS), as predictors of mortality in the early post traumatic period, in 100 Turkish patients with blunt head trauma. Overall patient mortality was 27%. There was a significant association between age and mortality, and mortality was negatively correlated with GCS and RTS. Head injury severity (GCS) was significantly related to NSE, hs-CRP, interleukin (IL)-6, IL-8 and tumour necrosis factor (TNF)-α levels. Mortality correlated positively with IL-6, IL-8, TNF-α and hs-CRP levels. NSE, hs-CRP, IL-6, IL-8 and TNF-α levels were significantly higher in non-survivors compared with survivors. GCS score ≤ 8, younger age and NSE levels were significant independent predictors of mortality. During the early post-traumatic period, NSE may be an objective alternative criterion to the GCS, in the management of patients with blunt head trauma. © 2010 Field House Publishing LLP.