Comparison of Onset Times and Hemodynamic Changes of Bupivacaine and Levobupivacaine Used in Spinal Anesthesia Spinal Anestezide Kullanılan Bupivakain ve Levobupivakainin Başlangıç Süreleri ve Hemodinamik Değişikliklerinin Karşılaştırılması

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Uzun U., İdin K.

Anatolian Journal of General Medical Research, cilt.35, sa.2, ss.116-121, 2025 (Scopus, TRDizin)

Özet

Objective: The present study compared the motor and sensory onset times and hemodynamic effects of bupivacaine and levobupivacaine used in spinal anesthesia. The aim was to assess whether levobupivacaine is a safer alternative. Methods: The study included 50 patients who were classified as American Society of Anesthesiologists I-II and scheduled for inguinal hernia surgery. The patients were divided into two groups as bupivacaine (0.5%) and levobupivacaine (0.5%). In both groups, motor and sensory block onset times and hemodynamic parameters were evaluated following the administration of spinal anesthesia. Results: In the levobupivacaine group, the motor block onset time was found as 8.99 minutes and the sensory block onset time as 8.47 minutes. In the bupivacaine group, these times were recorded as 3.54 minutes and 3.26 minutes, respectively (p<0.001). No significant difference was found between the groups in terms of hemodynamic parameters. Despite having longer motor and sensory block onset times compared to bupivacaine, levobupivacaine achieved adequate anesthesia, with no difference between the two groups in terms of hemodynamic changes. Conclusion: Levobupivacaine has been shown to be an effective and safe alternative in spinal anesthesia. However, there is a need for larger-scale studies to generalize these findings.