The effect of basal heart rate on the antihypertensive efficiency of beta-blocker treatment
Turk Kardiyoloji Dernegi Arsivi, cilt.35, sa.7, ss.423-426, 2007 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 7
- Basım Tarihi: 2007
- Dergi Adı: Turk Kardiyoloji Dernegi Arsivi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.423-426
- Anahtar Kelimeler: Adrenergic beta-antagonists, heart rate, hypertension/drug therapy, metoprolol/therapeutic use.
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: Beta-blockers are widely used in the treatment of hypertension. Although decrease in heart rate has a major role in beta-blocker treatment, data are limited on the association between heart rate and the effectiveness of beta-blockers. This study was designed to evaluate the effect of basal heart rate on the efficiency of beta-blocker treatment in patients with essential arterial hypertension. Study design: This prospective study included 20 patients (13 males, 7 females, mean age 53±10 years) with grade I/II essential hypertension, who did not receive any antihypertensive drugs and did not have any disease affecting the heart rate. Following 24-hour ambulatory blood pressure monitoring for daytime and nighttime systolic, diastolic, and arterial blood pressures, and mean heart rates, oral metoprolol succinate treatment (50 mg/day) was started. At the end of 20 days, 24-hour ambulatory blood pressure monitoring was repeated. Results: There were significant decreases in mean day-time systolic, diastolic, and arterial (p<0.001) blood pressures (p<0.001) with corresponding decreases in night-time blood pressures (p=0.021, p=0.039, and p<0.001, respectively). Changes in daytime and nighttime mean heart rates were also significant (p<0.001). There was a significant correlation between the daytime basal heart rate and the decline in daytime arterial blood pressure (r=0.666, p=0.001). ROC (receiver operating characteristics) curve analysis showed that patients with a daytime basal heart rate of 72/min or higher had a significantly greater reduction in arterial blood pressure (p=0.04). Conclusion: Our results suggest that patients with higher basal heart rates benefit more from beta-blocker treatment for arterial hypertension.