The relationship Between Disease Activity and Systemic Inflammation Index and Platelet Albumin Ratio in Patients with Ankylosing Spondylitis Ankilozan Spondilit Hastalarında Hastalık Aktivitesi ile Sistemik İnflamasyon İndeksi ve Trombosit Albumin Oranı Arasındaki İlişki
Sakarya Medical Journal, cilt.13, sa.3, ss.361-368, 2023 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 3
- Basım Tarihi: 2023
- Doi Numarası: 10.31832/smj.1288358
- Dergi Adı: Sakarya Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.361-368
- Anahtar Kelimeler: Ankylosing Spondylitis, C-reactive protein albumin ratio, platelet albumin ratio, systemic inflammation index
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction Materials and Methods Results Conclusion Systemic Inflammation index (SII) and platelet albumin ratio (PAR) are new biomarkers proposed to evaluate inflammation. In our study, we aimed to examine the relationship between disease actıvıty and SII and PAR in patients with Ankylosing Spondylitis (AS). 79 patients with AS and 79 healthy controls were evaluated retrospectively. Demographic, clinical and laboratory data of the participants were recorded through the hospital information system by examining the outpatient clinic data. Disease activity status in the AS group was determined by calculating the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score. Those with a BASDAI score of ≥4 were considered active patients. AS patients with active disease and patients in remission were compared in terms of SII and PAR. The mean age of the AS group was 42.53±6.60, and the healthy group was 41.37±10.86 years (p=0.460). 49 (62.0%) participants in the AS group and 35 (44.3) participants in the healthy group were male (p=0.026). SII, PAR and C-reactive protein albumin ratio (CAR) values were found to be statistically significantly higher in the AS group compared to the healthy group (p<0.001, p=0.037, p=0.046, respectively). The median duration of complaints of AS patients was 156.0 [130.0], and the duration of diagnosis was 96.0 [85.0] months. According to the BASDAI score, 42 (54.5%) patients were active and 35 (45.5%) patients were in remission. While CRP and CAR values were found to be statistically significantly higher in patients in active period than in patients in remission (p=0.035, p=0.038, respectively); there was no significant difference between SII and PAR levels (p>0.05). SII and PAR values were found to be increased in AS patients when compared to healthy controls. Contrary to expectations, no relationship was found between disease activity and SII and PAR values.