The interaction between IL-1β and morphine: Possible mechanism of the deficiency of morphine-induced analgesia in diabetic mice
Pain, cilt.89, sa.1, ss.39-45, 2000 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 89 Sayı: 1
- Basım Tarihi: 2000
- Doi Numarası: 10.1016/s0304-3959(00)00343-2
- Dergi Adı: Pain
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.39-45
- Anahtar Kelimeler: interleukin-1 beta, morphine, streptozotocin, diabetes, mice
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
It is known that diabetic mice are less sensitive to the analgesic effect of morphine. Some factor(s) derived from mononuclear cells, e.g. interleukin-1β (IL-1β), may be responsible for the diminished analgesic effect of morphine in diabetic mice. Therefore, we examined direct effects of IL-1β, intracerebroventricularly (i.c.v.), on morphine-induced analgesia, subcutaneously (s.c.), in diabetic and control mice by using the tail-flick test. Morphine at doses of 1, 2 and 5 mg/kg (s.c.) produced dose-dependent analgesia in diabetic and control mice but diabetic mice were less sensitive to the analgesic effect of morphine when compared to the controls. IL-1β at a dose of 0.1 ng/mouse produced analgesia in control mice but not in diabetics, whereas IL-1β at a dose of 10 ng/mouse produced a hyperalgesic effect both in diabetic and control mice. IL-1β at a dose of 1 ng/mouse has neither an analgesic nor a hyperalgesic effect in control and diabetic mice. Administration of a neutral (neither analgesic nor hyperalgesic) dose of IL-1β, 1 ng/mouse (i.c.v.), just prior to administration of morphine (s.c.) abolished the analgesic effect of morphine at doses of 1, 2 and 5 mg/kg in control mice and the analgesic effect of morphine became similar to that in diabetics. The diminished analgesic effect of morphine in diabetes was attenuated further with IL-1β at a dose of 1 ng/mouse (i.c.v.). These results suggest that the decreased analgesic effect of morphine in diabetes may be related to IL-1β. Copyright (C) 2000 International Association for the Study of Pain.