A case of systemic amyloidosis associated with multiple myeloma diagnosed with skin findings Deri Bulgularıyla Tanı Konulan Multipl Miyelomla İlişkili Bir Sistemik Amiloidoz Olgusu
Turkiye Klinikleri Dermatoloji, cilt.30, sa.1, ss.30-34, 2020 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 1
- Basım Tarihi: 2020
- Doi Numarası: 10.5336/dermato.2019-65508
- Dergi Adı: Turkiye Klinikleri Dermatoloji
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, CAB Abstracts, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.30-34
- Anahtar Kelimeler: Amyloidosis, Multiple myeloma, Skin manifestations
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Amyloidosis is a disease characterized by accumulation of a proteinous substance called amyloid of tissues and organs for primary or secondary reasons. Primary systemic amyloidosis is a rare form of amyloidosis and may present alone or in combination with plasma cell dyscrasias. Multiple myeloma (MM), one of the plasma cell dyscrasias, may lead to many skin manifestations, and amyloidosis develops in 30-40% of patients. In the presence of skin involvement, hemorrhagic lesions such as ecchymoses, petechiae, and waxy, smooth shiny papules, nodules are observed. The cutaneous lesions occur most frequently on face and intertriginosis sites. Multiple biopsies should be performed in case of suspected amyloidosis. A 71-year-old female patient admitted to our clinic with lesions characterized by ecchymoses, purpura and papules, which have been present for nearly 1 year. The patient was diagnosed with amyloidosis by the skin and gingiva biopsy, serum and urine electrophoresis and bone marrow biopsies yielded the diagnosis of MM. We present a case of primary systemic amyloidosis and MM diagnosed by skin findings.