Drug-Induced Enterocolitis Syndrome with AmoxicillinClavulanic Acid and Alternative Beta Lactam Antibiotic
Asthma Allergy Immunology, cilt.22, sa.3, ss.329-332, 2024 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 3
- Basım Tarihi: 2024
- Doi Numarası: 10.21911/aai.2024.578
- Dergi Adı: Asthma Allergy Immunology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.329-332
- Anahtar Kelimeler: alternative antibiotic, amoxicillin/clavulanic acid, drug-induced enterocolitis syndrome, Pediatric
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Drug-induced enterocolitis syndrome (DIES) is a rare hypersensitivity reaction characterized by delayed gastrointestinal symptoms following ingestion of triggering medications. We report the case of a seven-year-old male presenting with symptoms consistent with DIES after receiving amoxicillin-clavulanic acid (AMX/CLV) for tonsillitis and soft tissue infection. The patient experienced recurrent vomiting and lethargy 2-3 hours post-administration of AMX/CLV. Following supportive care and clarithromycin treatment, the symptoms resolved. Oral provocation testing with AMX/CLV resulted in severe abdominal pain, vomiting, and lethargy, confirming DIES. Patch testing with various beta-lactam antibiotics yielded negative results. Subsequent oral provocation with cefuroxime axetil showed no adverse reactions, suggesting an alternative. This case highlights the importance of considering DIES as a differential diagnosis in patients presenting with delayed gastrointestinal symptoms following drug intake. Identifying alternative antibiotics is crucial for the management of such cases.