Isolated itching of external auditory canal: Clinicopathological study with immunohistochemical determination of antimicrobial peptides
Journal of Laryngology and Otology, cilt.125, sa.3, ss.227-230, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 125 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.1017/s0022215110002161
- Dergi Adı: Journal of Laryngology and Otology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.227-230
- Anahtar Kelimeler: External Auditory Canal, Otitis Externa, Pruritus
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: This study aimed to demonstrate the histological and immunohistological features of skin biopsy specimens from patients complaining of isolated itching of the external auditory canal.Materials and methods: A prospective, case-control study was performed of 24 patients undergoing evaluation for contact dermatitis of the external auditory canal, and 24 controls. Skin biopsies were examined histologically by a single, blinded dermatopathologist, using light microscopy, to determine histopathological characteristics. The immunohistological presence of the antimicrobial peptides human β-defensin-3 and LL-37 cathelicidin was also assessed. Findings for patients and controls were compared.Results: There was a statistically significant difference in the degree of inflammation, comparing patients and controls (p<0.05). There was no significant difference in the presence of spongiotic changes, comparing patients and controls (p>0.05). Furthermore, the patients' skin biopsies did not show pronounced expression of human β-defensin-3 or LL-37 cathelicidin.Conclusion: Histological and immunohistological examination of skin biopsies from cases of isolated itching of the external auditory canal did not support a diagnosis of dermatitis. © 2010 JLO (1984) Limited.