Relationship between D-dimer and systemic embolism in patients with infective endocarditis Enfektif endokarditli hastalarda D-dimer düzeyinin sistemik emboliyle ilişkisi

Bakal R. B., Karakoyun S., Kahveci G., Özveren O., Omaygenç O., Akpinar S. H., ...Daha Fazla

Turk Kardiyoloji Dernegi Arsivi, cilt.41, sa.7, ss.589-594, 2013 (Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 7
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5543/tkda.2013.02058
  • Dergi Adı: Turk Kardiyoloji Dernegi Arsivi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.589-594
  • Anahtar Kelimeler: Endocarditis bacterial/etiology therapy, embolism/blood, D-dimer, blood coagulation
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objectives: The aim of this study was to investigate the value of plasma D-dimer (DD) levels for predicting systemic embolism in patients with infective endocarditis (IE). Study design: A total of 42 patients (mean age: 46±16 years; 78% males) with IE were included. Clinical, laboratory and echocardiographic fndings of the patients were evaluated. Results: Increased plasma DD levels were determined in 13 patients with systemic embolism (p=0.016). Moreover, when patients were divided in two groups as DD >500 ng/dl and DD <500 ng/dl, systemic embolism was increased in the DD >500 ng/dl group (p=0.036). Receiver operating characteristics (ROC) curve analysis was performed to detect the best cut-off value of DD in the prediction of systemic embolism. DD >425 ng/dl yielded an area under the curve (AUC) value of 0.735 (95% CI 0.560-0.909, p=0.016). DD >425 ng/dl demonstrated a sensitivity of 77% and specifcity of 62% for the prediction of clinical embolism. Hematocrit (r=-0.31, p=0.045), platelet count (r=-0.40, p=0.009), albumin (r=-0.37, p=0.026), and globulin (r=0.38, p=0.028) levels were correlated with DD levels. Conclusion: Plasma DD levels are increased in patients with IE who suffered from clinically signifcant systemic embolism. Further studies are needed to determine the predictive value of DD levels for clinically silent systemic embolism. © 2013 Türk Kardiyoloji Derneǧi.