Febril neutropenia etiology in a hematology department
European Journal of General Medicine, cilt.5, sa.4, ss.228-231, 2008 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 5 Sayı: 4
- Basım Tarihi: 2008
- Doi Numarası: 10.29333/ejgm/82612
- Dergi Adı: European Journal of General Medicine
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.228-231
- Anahtar Kelimeler: Antibiotic treatment, Febrile neutropenia, Hematological malignancies
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: Chemotherapy-induced febrile neutropenia (FN) predisposes patients to life-threatening infections and typically requires hospitalization. Patients with profound neutropenia have increased risk of septicemia associated with significant morbidity. To provide the appropriate broad-spectrum antimicrobial cover, documentation of causative agents and their antimicrobial susceptibilities should be established in each hospital. Methods: The goal of the present study was to investigate the causative microorganisms in 27 febrile neutropenic patients between January 2006 and December 2007. Results: ln our hematology unit, among 122 febrile neutropenic episodes 57 isolates from cultures of febrile neutropenic patients, gram-negative bacteria was prevalent (45.6%). Among the gram-positives (%42.1% of isolates) coagulase-negative staphylococci (CNS) were the predominant bacteria (13/23) followed by Staphylococcus aureus (7/23). Escherichia coli (14/26) and Klebsiella spp. (7/26) were the most common species among 26 gram-negative bacteria. Conclusion: The most important issue in febrile neutropenia is still a mortal situation in immunocompromised patients. So documentation of the flora in each unit would help to decide appropriate empirical therapy which is life saving.