Benign transient hyperphosphatasemia in the pediatric population: A single center cohort study
Journal of Pediatric Endocrinology and Metabolism, cilt.37, sa.7, ss.622-629, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 7
- Basım Tarihi: 2024
- Doi Numarası: 10.1515/jpem-2024-0123
- Dergi Adı: Journal of Pediatric Endocrinology and Metabolism
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.622-629
- Anahtar Kelimeler: alkaline phosphatase, benign transient hyperphosphatasemia, bone disorders, respiratory infection
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: Alkaline phosphatase (ALP) can be increased in a benign condition known as benign-transient hyperphosphatasemia (BTH). We aimed to evaluate the demographic, and clinical characteristics of infants and children with BTH. Methods: In our retrospective study, infants and children diagnosed with BTH between September 2019 and September 2023 were included. Results: Of 249 children with elevated ALP levels, 95 (38.1%) had BTH. The mean age at diagnosis of children with BTH was 2.4 ± 1.3 years (min 0.6 - max 6.2 years). ALP mean value was 2,587 ± 1252U/L (min 972 - max 5757U/L). ALP value was an average 7.4 ± 3.6 times higher than the corresponding upper limit of normal. The second measurement was made after an average of 13.2 ± 6 days, and a statistically significant difference was detected compared to the first value, with a decrease of 61 ± 23% in the ALP value (p<0.001). ALP value returned to normal in an average of 44 ± 29.2 days. Elevated ALP was detected during infection in 49 (51.6%) children. When the sample was divided into those under 2 years of age and aged 2 and over, no statistical difference was observed in ALP levels in the time it took for ALP levels to return to the normal range (p=0.480). Conclusions: BTH should be kept in mind if high serum ALP is detected in children without clinical or laboratory suspicion of bone or liver disease. In the follow up detecting a significant decrease trend compared to the first value may be guiding for BTH.