Autoimmune hepatitis and primary biliary cholangitis overlap syndrome after mRNA COVID-19 vaccination
Gulhane Medical Journal, cilt.65, sa.3, ss.141-144, 2023 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 65 Sayı: 3
- Basım Tarihi: 2023
- Doi Numarası: 10.4274/gulhane.galenos.2023.66376
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, CAB Abstracts, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.141-144
- Anahtar Kelimeler: Autoimmune hepatitis, COVID-19 vaccine, mRNA vaccine, overlap syndrome, primary biliary cholangitis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The overlap syndrome indicates an association between autoimmune hepatitis (AIH) and sclerosis cholangitis or primary biliary cholangitis (PBC). We report a case of a 32-year-old patient who experienced overlap syndrome ten days after receiving the first dose of the mRNA Coronavirus disease-2019 (COVID-19) vaccine. Liver biopsy showed primarily AIH and “overlap syndrome” for PBC. Serum IgG was elevated, and ANA (1/100) and anti-mitochondrial antibody was positive. The patient’s treatment plan included prednisolone, ursodeoxycholic acid and azathioprine. Overlap syndrome related to the mRNA COVID-19 vaccines is a very rare entity. After the histopathological diagnosis of the patient, remission was achieved following treatment.