Protective effects of passiflora incarnata on ovarian ischemia/reperfusion damage in rats with ovarian torsion Over torsiyonu olan sıçanlarda Passiflora incarnata'nın overin iskemi/reperfüzyon hasarı üzerinde koruyucu etkileri

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Arslan S., Aşır F., GÖKALP ÖZKORKMAZ E., Azizoğlu M., Basuguy E., Okur M. H., ...Daha Fazla

Ulusal Travma ve Acil Cerrahi Dergisi, cilt.29, sa.12, ss.1344-1350, 2023 (SCI-Expanded, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 12
  • Basım Tarihi: 2023
  • Doi Numarası: 10.14744/tjtes.2023.52986
  • Dergi Adı: Ulusal Travma ve Acil Cerrahi Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, MEDLINE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1344-1350
  • Anahtar Kelimeler: Ischemia reperfusion, passiflora incarnata, ovarian torsion, ovarian damage, oogenesis
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

BACKGROUND: This study aimed to investigate whether Passiflora Incarnata (PI) has a protective effect against ischemia-reperfu-sion (IR)-induced oxidative and inflammatory ovarian damage.METHODS: The effects of PI on ovarian ischemia-reperfusion injury were investigated in female Wistar albino rats. The animals were randomly divided into three groups: Group 1 (sham), Group 2 (IR), and Group 3 (IR+PI).RESULTS: The mean levels of Malondialdehyde (MDA), Myeloperoxidase (MPO), and Total Oxidant Status (TOS) were higher in the IR group (p=0.025, p<0.001, and p=0.016, respectively). The Total Antioxidant Status (TAS) levels were lower in the IR group (p=0.005). Immunostaining revealed significant differences across the groups for Tumor necrosis factor-alpha (TNF-α): 13.84%, 49.51%, and 22.51% for Groups 1, 2, and 3, respectively (p<0.01). Bax: 10.53%, 46.74%, and 26.46% for Groups 1, 2, and 3, respectively (p<0.01). Annexin V: 12.24%, 44.86%, and 23.28% for Groups 1, 2, and 3, respectively (p<0.01). The mean scores for hemorrhage, inflammation, follicular degeneration, and congestion showed significant variations among the groups, all registering p<0.001.CONCLUSION: Passiflora Incarnata exhibited antioxidant, anti-inflammatory, and anti-apoptotic properties, promoting cell survival, histologically protecting ovarian tissue, and ameliorating IR injury by reducing oxidative stress.