Despite the increase of serum CA 19-9, complete metabolic response and tumoral calcifications in PET/CT: Could it be a tumor stunning after chemotherapy? Malgré l'augmentation du CA 19-9 sérique, réponse métabolique complète et calcifications tumorales en TEP/TDM : serait-ce une tumeur étourdie après chimiothérapie?
Medecine Nucleaire, cilt.46, sa.4, ss.191-193, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 4
- Basım Tarihi: 2022
- Doi Numarası: 10.1016/j.mednuc.2022.02.003
- Dergi Adı: Medecine Nucleaire
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Sayfa Sayıları: ss.191-193
- Anahtar Kelimeler: Gastric non-mucinous adenocarcinoma, Tumor stunning, CA 19-9, FDG PET/CT, Tumor calcification
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
A 74-year-old male patient with a history of nausea, vomiting, and loss of appetite revealed thickening of the antrum and pylorus in gastroscopy and non-mucinous adenocarcinoma was diagnosed in the biopsy. The patient underwent 18F-FDG PET/CT for staging. PET/CT showed intense FDG uptakes in the primary lesion, locoregional lymph nodes and liver metastases. After 5-fluorouracil based chemotherapy, a complete metabolic response in metastatic liver lesions, lymph nodes, and the primary tumor was detected. Furthermore, tumor calcifications were observed in the liver and locoregional lymph node metastases. Although a complete response, there was a 40 percent serum CA 19-9 level increase. During the follow-up, intense FDG uptake was observed in the calcified metastatic liver lesions and some lymph nodes, similar to the continuous increase in serum CA 19-9 levels. Ascites, multiple metastatic lung nodules and metabolic progression in liver lesions were observed on PET/CT in the patient who continued to receive chemotherapy.