Comparison of sugammadex and neostigmine in short term surgery Kısa süreli cerrahide sugammadeks ile neostigminin karşılaştırılması
Journal of Clinical and Analytical Medicine, cilt.6, sa.1, ss.41-45, 2015 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6 Sayı: 1
- Basım Tarihi: 2015
- Doi Numarası: 10.4328/jcam.1694
- Dergi Adı: Journal of Clinical and Analytical Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.41-45
- Anahtar Kelimeler: Sugammadex, Neostigmine, Neuromuscular Blockade
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: This study compared the efficacy and cost effectivines of sugamma-dex and neostigmine for reversal of neuromuscular blockade induced by ro-curonium for short term elective surgery. Material and Method: After written informed consent, 33 patients aged 18–65, ASA I-III, who were undergoing short term surgery (<90 min) were randomly selected and divided into two groups (Group Sugamadex, n=16; group Neostigmine, n=17). All patients were given 1,5 μg kg-1 fentanyl, 5-7 mgkg-1 thiopental, 0,6 mg kg-1 ro-curonium for anaesthesia induction. Anaesthetic maintenance was ensured through 50% O2-N2O and 1% sevoflurane. Neuromuscular blockade was monitored using acceleromyography and a train-of-four (TOF) mode of stim-ulation. During surgery maintenance doses of 0.1-0.2 mgkg-1 rocuronium were administered according to reappearance of the third response of the TOF. Patients were given sugammadex 2 mg kg_1(group S) or neostigmine 50 μg kg_1 (with atropine 20 μg kg_1) (group N) at reappearance of the second response of the TOF after the last dose of rocuronium in the end of the surgery. Results: Demographic properties were similar in the two groups. Time to recovery of the TOF ratio of 0.9 and extubation time after sugam-madex compared with neostigmine were significantly shorter, being 2.3 ± 0.9 versus 9.4 ± 2.7 min and 6.6 ± 1.6 versus 12.9 ± 2 (P<0.001). The costs were higher in group S (71.2 ± 9.8 $) than group N (1.7 ± 0.2 $) per patient (p<0.001). Discussion: Recovery of neuromuscular function after rocuronium to a TOF ratio of 0.9 was faster with 2mg kg_1 sugammadex when com-pared with 50 μg kg_1 neostigmine, while sugammadex was the more ex-pensive then neostigmine.