68Ga PSMA PET/CT and 18F FDG PET/CT Findings in Osteonecrosis of the Jaw Induced by Denosumab
Clinical Nuclear Medicine, cilt.50, sa.9, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 9
- Basım Tarihi: 2025
- Doi Numarası: 10.1097/rlu.0000000000005751
- Dergi Adı: Clinical Nuclear Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: prostate cancer, denosumab, osteonecrosis of the jaw
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Breast cancer, prostate cancer, kidney cancer, multiple myeloma, osteoporosis, and the use of antiresorptive and antiangiogenic drugs are risk factors for osteonecrosis of the jaw (ONJ). Denosumab is a Receptor activator of nuclear factor kappa-I ligand antagonist monoclonal antibody that inhibits the differentiation and function of osteoclasts over osteoblasts. It is an antiresorptive drug used to reduce the development of skeletal events in solid cancers. Denosumab-induced ONJ is a rare condition, occurring in 0% to 4.6% of cases. In this case, the findings of 68Ga prostate specific membrane antigen (PSMA) positron emission tomography (PET)/Computed Tomography (CT) and 18F Fluorodeoxyglucose (FDG) PET/CT are presented in a man with metastatic castration-resistant prostate cancer who developed ONJ due to denosumab use.