A Case of Concomitant Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma and Graves’ Disease with Ophthalmopathy Appeared After Coronavirus Disease 2019 Vaccine
Endocrinology Research and Practice, cilt.28, sa.1, ss.56-59, 2024 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 1
- Basım Tarihi: 2024
- Doi Numarası: 10.5152/erp.2024.23252
- Dergi Adı: Endocrinology Research and Practice
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.56-59
- Anahtar Kelimeler: Diffuse sclerosing subtype of papillary thyroid carcinoma, Graves' disease, Graves' ophthalmopathy, COVID-19 vaccine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
It is known that the risk of developing thyroid carcinoma is increased in patients with Graves’ disease (GD). Some reports document how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination or infection could represent new external triggers for autoimmune thyroid disease such as GD in patients with individual predisposition. We describe GD and Graves’ ophthalmopathy (GO) in a 27-year-old male patient 15 days after inactivated coronavirus disease 2019 (COVID-19) vaccine. Given the ophthalmopathy and uncontrolled hyperthyroidism, a thyroidectomy decision was made. Histopathological examination revealed a diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC), and GD was detected in the parenchyma of non-neoplastic thyroid tissue. Various environmental, genetic, and epigenetic factors that initiate the development of GD are known, and cases of GD after COVID-19 vaccination have also been reported. However, the etiology of GD after COVID-19 vaccination has not been fully elucidated in the literature. In addition, the DSV-PTC is a rare sub-type of papillary thyroid carcinoma, and its association with GD has been reported in very few cases. Interestingly, we report for the first time a case of DSV-PTC associated with GD histopathologically following inactivated COVID-19 vaccine. The molecular mechanisms of extremely rare co-existence in our case have aroused curiosity and need to be clarified by further studies.