Clinical correlates and prognostic significance of cardiopulmonary recovery time after 6-minute walk test in COPD versus interstitial lung disease patients

Yıldırım E., Tutuş N., Aydogdu Y., ÖZMEN İ.

Heart and Lung, cilt.74, ss.19-26, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.hrtlng.2025.06.001
  • Dergi Adı: Heart and Lung
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE
  • Sayfa Sayıları: ss.19-26
  • Anahtar Kelimeler: COPD, Interstitial lung disease, 6-min walk test, Cardiopulmonary recovery time
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background: Cardiopulmonary recovery time after 6-min walk test (6MWT) is a novel and easily interpretable marker of clinical outcomes, which has not been studied yet in the setting of chronic obstructive pulmonary disease (COPD) versus interstitial lung disease (ILD). Objectives: This study aimed to investigate clinical correlates and prognostic significance of cardiopulmonary recovery time after 6MWT in COPD versus ILD patients. Methods: A total of 117 patients with COPD (n = 52) or ILD (n = 65) were evaluated in terms of pulmonary function, disease impact and 6MWT parameters including 6-min walk distance (6MWD) and cardiopulmonary recovery time. Predictors of adverse clinical outcomes (emergency admissions, hospitalizations, mortality) were also evaluated via multivariate logistic regression analysis. Results: The 6MWD was significantly shorter in the COPD group than in the ILD group (median(min-max) 389.5(84.0­597.0) vs. 476.0(120.0­635.0) m, p < 0.001). SpO2 recovery time (r=-0.370, p = 0.037) and HRR time (r=-0.425, p = 0.017) were negatively correlated with DLCO in the ILD group. Increase in SpO2 recovery time predicted increased risk of overall adverse clinical outcomes in the ILD group (OR 1.009, p = 0.040). HRR time had no significant role in predicting the risk of adverse clinical outcomes in COPD and ILD groups. Conclusions: Our findings suggest that SpO2 recovery time during 6MWT may be a simple and practical novel marker to determine risk for future emergency admissions, hospitalizations and mortality in ILD patients but not in COPD patients. HRR time had no significant role in predicting adverse clinical outcomes in both COPD and ILD groups.