Vitamin B12 deficiency associated with three-month use of proton-pump inhibitor in a child with chronic graft-versus-host disease Kronik graft versus host hastaliği olan bir olguda üç ay süreli proton pompa inhibitörü kullanimina bağli gelişen vitamin B12 eksikliği
Gulhane Medical Journal, cilt.58, sa.2, ss.197-199, 2016 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 58 Sayı: 2
- Basım Tarihi: 2016
- Doi Numarası: 10.5455/gulhane.172354
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.197-199
- Anahtar Kelimeler: Proton-pump inhibitors, Vitamin B12 deficiency
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Prolonged use of proton-pump inhibitors (PPI) may result in vitamin B12 deficiency as a consequence of impaired release of protein-bound dietary vitamin B12 from food in a nonacid environment. Herein, we described a case of vitaminB12 deficiency associated with three months use of PPI which was used to reduce gastric side effects of steroid in a patient with chronic graft versus host disease (cGVHD). Malabsorption of proteinbound vitamin B12 has been demonstrated with the prolonged use of PPI. Although monitoring these patients is not routinely recommended for side effects, patients with chronic disease should be followed-up more carefully.