Serotonin and vasoconstrictor synergism
Life Sciences, cilt.62, sa.19, ss.1723-1732, 1998 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Kısa Makale
- Cilt numarası: 62 Sayı: 19
- Basım Tarihi: 1998
- Doi Numarası: 10.1016/s0024-3205(97)01166-1
- Dergi Adı: Life Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1723-1732
- Anahtar Kelimeler: serotonin, contraction, synergism
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Contractile synergism between serotonin (5-hydroxytryptamine, 5-HT) and other vasoconstrictor substances has been observed in a number of peripheral and cerebrovascular blood vessels. This phenomenon may play an important role in certain pathological states such as hypertension, peripheral vascular disease, and coronary spasm. In the present review, we summarize studies on the synergism between serotonin and other vasoconstrictor agents and focus on n recently described type of vasoconstrictor synergism in which precontraction with a non-5-HT receptor agonist yields an enhanced contractile response to serotonin which is mediated by previously inactive or 'silent' 5-HT receptor subtypes.