PENTRAXIN 3 LEVELS CORRELATE WELL WITH DISEASE SEVERITY AT ADMISSION IN COVID-19 PATIENTS RAZINE PENTRAKSINA 3 DOBRO SU POVEZANE S TEŽINOM BOLESTI KOD PRIJMA U BOLESNIKA S COVID-19
Acta Clinica Croatica, cilt.61, sa.2, ss.303-310, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 61 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.20471/acc.2022.61.02.17
- Dergi Adı: Acta Clinica Croatica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- Sayfa Sayıları: ss.303-310
- Anahtar Kelimeler: COVID-19, Pentraxin 3, Innate immunity, C-reactive protein, SARS-CoV-2
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Pentraxin 3 (PTX3), a long pentraxin, is not only released from dendritic cells and neutrophils but also from epithelial and endothelial cells such as alveolar epithelium. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initially activates the innate immune system, caus-ing a complex immune response. Clinical and experimental studies suggest that PTX3, a locally and systemically secreted marker, can be used as a predictor of the severity and mortality in respiratory in-fections. In the current study, serum PTX3 levels in patients hospitalized with COVID-19 were found to be significantly increased at admission and showed significant association with the disease severity.