The antioxidant effect of β-Glucan on oxidative stress status in experimental spinal cord injury in rats
Neurosurgical Review, cilt.28, sa.4, ss.298-302, 2005 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 4
- Basım Tarihi: 2005
- Doi Numarası: 10.1007/s10143-005-0389-2
- Dergi Adı: Neurosurgical Review
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.298-302
- Anahtar Kelimeler: beta-Glucan, spinal cord injury, lipid peroxidation
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
This study was performed to investigate the antioxidant effect of β-Glucan in experimental spinal cord injury (SCI). Injury was produced using weight-drop technique in rats. β-Glucan was given by intraperitoneal injection following trauma. The rats were sacrificed at the sixth day of injury. Oxidative stress status was assessed by measuring the spinal cord tissue content of Malonyldialdehyde (MDA), Superoxide Dismutase (SOD) and Gluthatione Peroxidase (GSH-Px) activities. No effect of β-Glucan on SOD and MDA activities was found but, GSH-Px levels were found to decrease to the baseline (preinjury) levels when it was compared to untreated group (U=0.000; p=0.002). According to our results, β-Glucan works like a scavenger and has an antioxidant effect on lipid peroxidation in spinal cord injury. © Springer-Verlag 2005.