Comparison of clinical features and survival between young and old chronic lymphocytic leukemia patients: a single center study from Turkey
Leukemia and Lymphoma, cilt.60, sa.3, ss.742-747, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 60 Sayı: 3
- Basım Tarihi: 2019
- Doi Numarası: 10.1080/10428194.2018.1509316
- Dergi Adı: Leukemia and Lymphoma
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.742-747
- Anahtar Kelimeler: Chronic lymphocytic leukemia, elderly, treatment demand, survival
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
We aimed to investigate whether the clinical characteristics, the rate of treatment demand and survival differ between chronic lymphocytic leukemia (CLL) patients <65 years (y) and ≥65 y. Sixty three (46%) patients were <65 y and 74 (54%) were ≥65 y. 28.6% (18/63) of the patients <65 required treatment, while this rate was 44.6% (33/74) for patients ≥65 y (p >.05). The probability of overall survival (OS) was 90 vs. 51% in patients <65 y and ≥65 y (p =.016). In univariate analysis, the age affected OS (p =.04, HR: 0.212, CI: 0.047–0.946). In subgroup analysis, in treated patients, the probability of OS was 73 vs. 49% in patients <65 y and ≥65 y (p =.389). The survival difference between the young and old patients is too high to be ignored and age seems to affect the outcome of CLL patients.