The role of Matrix Gla Protein gene variants (G-7 A and T-138 C) in susceptibility to ischemic stroke: a case-control study
Molecular Biology Reports, cilt.53, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 53 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s11033-026-11763-5
- Dergi Adı: Molecular Biology Reports
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE, Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
- Anahtar Kelimeler: Ischemic stroke, Matrix Gla Protein gene, PCR-RFLP, Polymorphism, rs1800801, rs1800802
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Matrix Gla Protein (MGP) plays a critical role in vascular calcification and extracellular matrix regulation, processes implicated in cerebrovascular pathology. This study aimed to evaluate the potential association between two MGP gene single nucleotide polymorphisms (SNPs), G-7 A (rs1800801) and T-138 C (rs1800802), and susceptibility to ischemic stroke. Methods and Results: A total of 230 individuals, including 115 patients with ischemic stroke and 115 healthy controls, were enrolled. Genomic DNA was extracted, and genotyping was performed using the PCR-RFLP method. Genotype and allele frequencies were statistically compared to assess their association with disease risk. No significant association was observed between the G-7 A polymorphism and ischemic stroke under genotype distribution or genetic models (p = 0.33; allelic model OR: 0.77, 95% CI: 0.52–1.14). In contrast, the T-138 C variant demonstrated statistically significant differences between groups (p = 0.015) and was associated with increased ischemic stroke risk under dominant (OR: 1.89, 95% CI: 1.12–3.19), recessive (OR: 3.54, 95% CI: 1.13–11.12), and allelic models (OR: 1.83, 95% CI: 1.20–2.78), suggesting a possible relationship with stroke susceptibility. Conclusions: These findings indicate that the MGP T-138 C polymorphism may contribute to ischemic stroke risk and could serve as a potential biomarker, whereas the G-7 A variant appears to be unrelated to disease susceptibility. Further large-scale studies are needed to confirm these results. This is the first study to evaluate this association in a Turkish population.