Relationship Between Non-diagnostic Result and Nodule Size in Thyroid Fine Needle Aspiration Biopsies Tiroid İnce İğne Aspirasyon Biyopsilerinde Non-diagnostik Tanı ile Nodül Boyutları Arasındaki İlişki
Medical Journal of Bakirkoy, cilt.21, sa.2, ss.127-133, 2025 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 2
- Basım Tarihi: 2025
- Doi Numarası: 10.4274/bmj.galenos.2025.2024.7-6
- Dergi Adı: Medical Journal of Bakirkoy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.127-133
- Anahtar Kelimeler: Nodule size, non-diagnostic, thyroid fine needle aspiration biopsy, ultrasonographic characteristics
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Twenty-one percent of total thyroid fine needle aspiration biopsies (FNABs) result non-diagnostic (ND). It is a major problem in management of thyroid nodules. The aim of this study is to investigate the relationship among ND result, nodule size, ultrasonographic features and laboratory findings in patients whose cytopathologic examination of thyroid FNABs resulted in ND. Methods: Retrospectively, 520 patients aged 18-85 years, whose thyroid FNABs were performed between the years 2012-2016 and whose cytopathology was ND, were evaluated with laboratory, ultrasonography, and final pathologic results. Results: There was no significant relationship among ND result, nodule size, and final pathology result. It was determined that no macrocalcifications were found in any of the ultrasonographic examinations of the nodules evaluated to be pathologically malignant. There was a significant relationship between the free triiodothyronine (fT3) level and the total number of biopsies taken from the same nodule. Significant relationship was observed between the anti-thyroid peroxidase (anti-TPO) level and the number of biopsies taken, which resulted in ND. In patients with high anti-TPO levels, an ND biopsy is one of the follow-up biopsies taken from the nodule. Conclusion: We concluded there is no distinct correlation between the ND result and nodule dimensions in the FNAB. Ultrasonographic features still cannot provide a prediction of whether the nodule is benign or malignant. Laboratory findings like fT3 and anti-TPO, may provide guidance to the clinical approach.