Species distribution and in vitro susceptibility of Candida bloodstream isolates to six new and current antifungal agents in a Turkish tertiary care military hospital, recovered through 2001 and 2006
Military Medicine, cilt.174, sa.8, ss.860-865, 2009 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 174 Sayı: 8
- Basım Tarihi: 2009
- Doi Numarası: 10.7205/milmed-d-04-7808
- Dergi Adı: Military Medicine
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.860-865
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Species distribution and antifungal susceptibility of Candida bloodstream isolates. Methods: 173 Candida species recovered front fungemic patients admitted to the largest tertiary-care military hospital between 2001 and 2006 in Ankara, Turkey evaluated retrospectively. Antifungal susceptibility of 95 isolates (45 Candida parapsilosis, 35 C. albicans, 7 C. tropicalis, 4 C. krusei, 3 C. glabrata, and 1 C. kefyr) was determined against fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and amphotericin B. Results: C. albicans was the most common yeast (48.0%), followed by C. parapsilosis. Almost all strains showed low minimal inhibitory concentration (MIC) values to all six antifungals tested. Only 2 of 45 C. parapsilosis isolates were resistant to fluconazole, one was susceptible in a dose-dependent manner (SDD) to itraconazole, and 14 were nonsusceptible to caspofungin. Conclusions: Increasing prevalence of C. parapsilosis emphasizes a need for better catheter care and continuous surveillance programs. Reprint and Copyright © by Association of Military Surgeons of U.S., 2009.