Effect on sexual life - A comparison between tibolone and continuous combined conjugated equine estrogens and medroxyprogesterone acetate
Gynecological Endocrinology, cilt.20, sa.4, ss.209-212, 2005 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 4
- Basım Tarihi: 2005
- Doi Numarası: 10.1080/09513590400027240
- Dergi Adı: Gynecological Endocrinology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.209-212
- Anahtar Kelimeler: menopause, tibolone, conjugated equine estrogens, medroxyprogesterone acetate, sexual life
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: To compare the effects of tibolone 2.5 mg with those of continuous combined conjugated equine estrogens 0.625 mg/day and medroxyprogesterone acetate 5 mg/day (CEE/MPA) on sexual life in postmenopausal women. Methods: Eighty women were randomized to treatment with either tibolone or continuous combined CEE/MPA. Subjects were asked about sexual desire, sexual excitement, sexual arousal, orgasm capacity, vaginal lubrication during sexual activity and dyspareunia before and after the treatment. Results: After 6 months of treatment, a total of 72 women completed the study. When tibolone was compared with continuous combined CEE/MPA, significantly higher scores were found for the items assessing sexual desire, sexual excitement, intercourse frequency and vaginal dryness (p < 0.05). Conclusion: This study indicates that both tibolone and continuous combined CEE/MPA treatment were associated with significant improvements in sexual function in postmenopausal women. However, tibolone treatment improved sexual function to a greater extent than continuous combined CEE/MPA. © 2005 Taylor & Francis Group Ltd.