Early Haemoglobin Oxygen Affinity as a Hypothesis-Generating Marker for Retinopathy of Prematurity Risk in Preterm Infants
Journal of Paediatrics and Child Health, cilt.62, sa.1, ss.61-65, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 62 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1111/jpc.70231
- Dergi Adı: Journal of Paediatrics and Child Health
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Sociology Source Ultimate (EBSCO)
- Sayfa Sayıları: ss.61-65
- Anahtar Kelimeler: haemoglobin oxygen affinity, neonatal hypoxia, P50, preterm infants, retinopathy of prematurity
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To investigate whether postnatal haemoglobin oxygen affinity (P50), derived from serial arterial blood gases, is associated with the risk of retinopathy of prematurity (ROP) in preterm infants, as a potential physiologic marker. Study Design: Retrospective cohort study. Methods: This study included 232 preterm infants born < 32 weeks gestation. Haemoglobin P50 and lactate values were calculated daily during the first week of life. The primary outcome was the development of any ROP; treatment-requiring (Type 1) ROP was a secondary endpoint. Associations were analysed using logistic regression and ROC analysis. Results: Infants who developed ROP had significantly higher Day 7 P50 values (mean 26.9 ± 1.8 mmHg) than those without ROP (26.1 ± 1.7 mmHg; p = 0.003). A Day 7 P50 > 26.4 mmHg was independently associated with ROP (OR 2.5; 95% CI 1.3–4.9), though predictive performance was modest (AUC 0.60). Lactate levels showed no association with ROP. P50 was not predictive of Type 1 ROP. Conclusion: Increased postnatal P50 may be modestly associated with ROP development, reflecting impaired oxygen delivery during early retinal vascularization. While not suitable for screening, P50 may serve as a physiologic marker warranting further mechanistic investigation.