Female adnexial tumor of probable wolffian origin (FATWO) without Ki-67 expression reflecting low malignant potential in a 55-year-old woman Elli beş yaşındaki bir kadında ki-67 ekspresyonu olmamasının düşük malign potansiyeli yansıttıǧı muhtemel olarak wolffian kaynaklı dişi adneksial tümör
Eurasian Journal of Medicine, cilt.44, sa.3, ss.172-175, 2012 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 44 Sayı: 3
- Basım Tarihi: 2012
- Doi Numarası: 10.5152/eajm.2012.40
- Dergi Adı: Eurasian Journal of Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.172-175
- Anahtar Kelimeler: FATWO, Immunostaining, Ki-67, Low malignant potential, Rare
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Female adnexial tumors of probable Wolffian origin (FATWO) are rare tumors derived from the remnants of the mesonephric duct. These tumors generally exhibit a low malignant potential, but recurrence and or metastasis is possible during the course of the disease accord- ing to the tumors' possible malignant potential. We report a case of FATWO without estrogen and progesterone receptors and with nega- tive immunostaining for Ki-67 (a proliferation marker) as a probable low-malignant-potential tumor. A 55-year-old woman presented with a complaint of heavy menstrual bleeding and pelvic pain. Pre- operative ultrasonographic evaluation revealed an intramural uter- ine leiomyoma of 4 cm in diameter and a right adnexial solid mass measuring 5 cm in diameter. Following total abdominal hysterecto- my and bilateral salpingo-oophorectomy, immunostaining based on the labeled streptavidin-biotin method was performed on sections from representative blocks of paraffin-embedded tissues sampled from the mass, revealing a low mitotic index with negative Ki-67 im- munostaining. Immunohistochemical staining with promising new markers and pathological investigation of the entire tumor are need- ed to determine the malignant behavior of an individual FATWO. Ki- 67 is a helpful marker for determining Wolffian duct tumors' potential malignant behavior.