New era of ocular drug delivery systems based on contact lenses
Fabad Journal of Pharmaceutical Sciences, cilt.45, sa.2, ss.161-174, 2020 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 2
- Basım Tarihi: 2020
- Dergi Adı: Fabad Journal of Pharmaceutical Sciences
- Derginin Tarandığı İndeksler: Scopus, EMBASE, International Pharmaceutical Abstracts, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.161-174
- Anahtar Kelimeler: Contact lenses, Drug delivery, Drug design, Hydrogels, Ocular, Polymers
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Ocular drug delivery belongs to the most useful topical administration routes. Ocular drugs are applied on the eye mostly as ocular drops. However, eye drops present many limitations such as poor eye retention time and rapid drug removal from tear drainage. currently, contact lenses as ophthalmic drug carriers have become very popular since they can extent the drug release time and therapeutic efficacy. it seems that contact lenses which are applied to the anterior chamber present extremely increased bioavailability above 50% which compared to low bioavailability of eye drops is highly beneficial. Moreover, via the topical delivery of ocular drug contact lenses side effects are diminished whereas patient compliance is improved. Despite their advantages, contact lenses as ophthalmic carriers have not been marketed yet. Nonetheless, the last decade, the research interest focused on developing novel contact lenses which can deliver controllable the drugs to the eye. in this review, we summarize the found on literature ocular drug delivery systems based on contact lenses according to their compounds, their designing methods as other characteristics. it can be said that in the foreseeable future more and more topical eye drug delivery systems will be appeared and contact lenses seem to provide the most desirable characteristics. Thus, the drug loaded contact lenses will bring a new evolution on the current marketed ocular formulations. to conclude, this review could be helpful for medical professionals, ophthalmologists and scientists of every subject who want to develop novel ocular contact lenses.