The association between βeta 2-microglobulin and bronchopulmonary dysplasia
Turkish Journal of Biochemistry, cilt.48, sa.1, ss.128-134, 2023 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 1
- Basım Tarihi: 2023
- Doi Numarası: 10.1515/tjb-2022-0133
- Dergi Adı: Turkish Journal of Biochemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Food Science & Technology Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.128-134
- Anahtar Kelimeler: beta 2-microglobulin, bronchopulmonary dysplasia, long-term morbidities, neonatal intensive care unit, preterm infants
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: Previous studies showed that increased urinary Beta 2-microglobulin (β2-M) level is associated with fetal inflammatory response and successfully predict bronchopulmonary dysplasia (BPD). We aimed to investigate the clinical utility of serum β2-M levels to predict BPD in preterm infants. Method: Infants born between May and November 2018 and whose gestational age (GA) was <32 weeks were included into the study. During routine blood work in the first couple of hours of life an extra 0.5 mL blood was drawn to study β2-M levels later on. β2-M levels were compared between infants who developed BPD or not. Results: Data analysis of 111 infants was performed. Out of 111 infants, 37 died before BPD diagnosis and out of the rest 74 infants, 38 (34.2%) were diagnosed with BPD. Mean GA was 28 ± 1.8 and 29.9 ± 1.4 weeks (p < 0.01) and mean birth weights (BW) were 1,086 ± 316 and 1,395 ± 348 g (p < 0.01) in BPD group and without BPD respectively. Demographic characteristics of the two groups were similar. While the white blood cell count, CRP and IL-6 levels were similar in both groups, β2-M levels were significantly higher in BPD group (4.84 ± 1.0 and 3.79 ± 0.95 mg/L, p = 0.01). Furthermore a weak correlation between β2-M level and BPD was observed (r = 0.23, p = 0.04). Conclusion: Serum β2-M levels which obtained in the early postnatal life could predict developing BPD. Monitoring β2-M levels in infants who have high clinical risk factors for BPD development may provide additional benefit in predicting BPD.