The partial virological response to Tenofovir monotherapy in naive patients with chronic hepatitis B
Journal of the Pakistan Medical Association, cilt.71, sa.2 A, ss.550-552, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 71 Sayı: 2 A
- Basım Tarihi: 2021
- Doi Numarası: 10.47391/jpma.1135
- Dergi Adı: Journal of the Pakistan Medical Association
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.550-552
- Anahtar Kelimeler: Chronic hepatitis B, Tenofovir, partial response, Entecavir, combination therapy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
We report two treatment-naïve cases, a 26-year-old female patient and a 59-year-old male patient who were followed up for chronic hepatitis B (CHB) at the department of Infectious Diseases and Clinical microbiology. A partial response subsequent to 12 months of Tenofovir Disoproksil (TDF) monotherapy presumably due to an antiviral-drug resistance was noted. A sustained viral response with TDF (245 mg) or Tenofovir Alafenamide (TAF, 25 mg) + Entecavir (ETV, 1 mg) combination therapy was observed after failure with TDF monotherapy. A combination therapy with TDF (245 mg) or TAF (25 mg) +ETV (1 mg) is efficacious in naïve patients with a partial response to TDF monotherapy.