Comparison of effects of m-TOR inhibitors and calcineurin inhibitor on SUPAR and ox-LDL levels in renal transplant recipients Comparación de los efectos de los inhibidores de m-TOR y el inhibidor de calcineurina sobre los niveles de SUPAR y ox-LDL en receptores de trasplante renal
Revista de Nefrologia, Dialisis y Trasplante, cilt.42, sa.1, ss.48-55, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 1
- Basım Tarihi: 2022
- Dergi Adı: Revista de Nefrologia, Dialisis y Trasplante
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Fuente Academica Plus, EMBASE, Directory of Open Access Journals, DIALNET
- Sayfa Sayıları: ss.48-55
- Anahtar Kelimeler: calcineurin inhibitor, early markers of inflammation, mTOR inhibitors, renal trasplant
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: We aimed to investigate the effect of different immunosuppressive regimens on SUPAR and ox-LDL levels which are early markers of inflammation in renal transplant recipients. Methods: A total number of 83 patients were enrolled in our study. While fourty-eight of those were received mTORi, thirty five patients were been receiving CNI. According to the immunosuppressive regimen patients were divided into CNI and m-TORi receving groups and serum SUPAR and ox-LDL levels were measured. Results: Log-SUPAR values were lower in the group receiving m-TORi (3.40 ± 0.1 vs 3.48 ± 0.4, p = 0.010). OxLDL / LDL levels were higher (0.0168 ± 005 vs 0.0132 ± 004, p = 0.009) in the CNI group. In linear regression analysis, a statistically significant relationship was detected between the use of m-TORi and log-SUPAR (β =-0.052, 95% CI [-0.224,-0.012], p = 0.041) . A negative and independent relationship was found between HT and log-SUPAR (β =-0.60, 95% CI--0.112,-0.018], p = 0.0024) and ox-LDL (β =-0.169 [-0.330,-0.008], p = 0.040). Very strong correlation (r = 1.0, p = <0.001) and independent relationship (β = 0.321 [0.313,0.330], p = <0.001) was detected between ox-LDL and SUPAR. Conclusion: As a result, when compared immunsuppression between m-TORi and CNI, the former was associated with lower SUPAR and oxLDL levels.