Facial granuloma annulare associated with borelia burgdorferi infection and seropositivity for p25, p30 and p31 proteins Borelia burgdorferi infeksiyonu ile ilişkili fasiyal granüloma anülare ve P25, P30 ve P31 proteinleri için seropozitiflik
Nobel Medicus, cilt.11, sa.3, ss.84-88, 2015 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 3
- Basım Tarihi: 2015
- Dergi Adı: Nobel Medicus
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.84-88
- Anahtar Kelimeler: Borellia burgdorferi, Granuloma annulare, Lyme disease, Molecular mimicry
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Lyme disease is a multisystemic infectious disease caused by Borrelia burgdorferi spirochetes, transmitted by ticks. Beside the typical clinical lesions of the disease, some other skin diseases associated with Borrelia burgdorferi infection have also been reported in recent years. In the article, we present a 39-year-old woman with facial granuloma annulare who was bitten by a tick 20 months ago. Beside the borrelial antibodies, other clinical and laboratory findings of the patient were normal. Histopathology of the lesion was compatible with granuloma annulare. Borrelia IgM was negative and IgG was positive in the ELISA test of the peripheral blood. In the Western immunoblotting test, anti-borrelia IgG was positive for p25, p30 and p31 proteins. Based on the findings, the lesion was thought to be associated with Borrelia burgdorferi infection and the patient was treated with doxycycline. The lesion completely disappeared 7 weeks after the initiation of the treatment. Our case was presented because no case of granuloma annulare associated with borrelia proteins of p25, p30, p31 have been reported in literature. Additionally, a possible cross-reaction of T-cell type which might have induced the lesion was discussed through the concepts of “molecular mimicry”.