No harmful effect of mycophenolate mofetil on liver regeneration: An experimental study
Transplantation Proceedings, cilt.44, sa.6, ss.1743-1746, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Özet
- Cilt numarası: 44 Sayı: 6
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.transproceed.2012.05.068
- Dergi Adı: Transplantation Proceedings
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1743-1746
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: The aim of this experimental study was to examine the effects of mycophenolate mofetil (MMF) on liver regeneration in a partial hepatectomy model. Methods: Rats were divided into 3 groups immediately following partial liver resection: saline, controls intraperitoneally (MMF; Group 1); MMF (15 mg/kg/d; Group II), and MMF (30 mg/kg/d; Group III). On days 3 and 7 following liver resection we humanely killed half of the rats in each group to measure alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and to evaluate Ki-67 using immunohistochemistry. We calculated liver regeneration rates. Results: The difference between ALT levels on days 3 and 7 was not significantly different among the groups (P =.157; P =.292; P >.05, respectively). The AST levels were significantly different at 3 days (P =.018) but not 7 days (P =.385). The Ki-67 level were different among groups at day 3 (P =.002) but not at day 7 (P =.290). Liver regeneration rates were not different among the groups either at 3 or at 7 days (P =.264 and P =.925, respectively). Conclusion: MMF stimulates mitosis but its effect on regeneration is not clear. MMF appeared to show no adverse effects on liver regeneration. © 2012 Elsevier Inc. All rights reserved.