A Case of Primary Renal Allograft Dysfunction Caused by Missed Monoclonal Disease
Experimental and Clinical Transplantation, cilt.22, sa.7, ss.572-575, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 7
- Basım Tarihi: 2024
- Doi Numarası: 10.6002/ect.2023.0155
- Dergi Adı: Experimental and Clinical Transplantation
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.572-575
- Anahtar Kelimeler: Kidney transplantation, Immunosuppression, Myeloma cast nephropathy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
We present an unusual etiology of primary renal allograft dysfunction attributed to myeloma cast nephropathy in a patient with no history of multiple myeloma before kidney transplant. The patient, a 54-year-old woman, had been on hemodialysis for 6 months before transplant for presumed diabetic nephropathy; she developed graft dysfunction immediately after transplant. Graft biopsy specimens were consistent with myeloma cast nephropathy, and she was treated with bortezomib, cyclophosphamide, and dexamethasone. She achieved a complete hematological response and regained excellent graft function 3 months after transplant. The patient then received autologous stem cell transplant 8 months after kidney transplant. To our knowledge, this is the second report of a successful graft outcome after chemotherapy and the first report treated with autologous stem cell transplantation after remission of monoclonal disease.