The frequency of extended-spectrum beta-lactamase and the rate of antibiotic resistance in Escherichia coli strains Escherichia Coli Suşlarında Genişlemiş Spektrumlu Beta - Laktamaz Sıklıǧı ve Antibiyotik Direnç Oranları
TAF Preventive Medicine Bulletin, cilt.12, sa.3, ss.291-296, 2013 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 3
- Basım Tarihi: 2013
- Doi Numarası: 10.5455/pmb.1-1345029174
- Dergi Adı: TAF Preventive Medicine Bulletin
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.291-296
- Anahtar Kelimeler: Antibiotic, ESBL, Escherichia Coli, Resistance
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
AIM: The resistance related with production of extended-spectrum beta-lactamase (ESBL) is an important problem that we face when we are treating infections caused by enterobacteriaceae. We aimed to evaluate the frequency of ESBL production in E. coli strains and the rate of antibiotic resistance isolated from in our microbiology laboratory. METHOD: E. coli strains isolated from various clinical specimens between January 2010 - December 2011 were assessed retrospectively. Resistances to ESBL-producing and non-producing E. coli and the rate of ESBL production according to the years were investigated. The results were compared with statistical analysis. RESULTS: The rate of ESBL producing E. coli was 21.9% in 2010, and 25% in 2011. There was no resistance to imipenem, meropenem, ertapenem and tigecycline in all strains. The resistance to antibiotics other than amikacin was statistically significant in ESBL producing E. coli compared to ESBL nonproducing E.coli (p<0.05). CONCLUSION: Surveillance studies guide appropriate antibiotic therapy and prevent development of resistance. Empiric treatment should be started according to local surveillance data, and de-escalation of the administered antibiotics should be used following culture results.