Two cases of the same family with the unusual elevation of CA19-9 levels Dois casos na mesma família com a elevação incomum de níveis de CA19-9
Acta Medica Portuguesa, cilt.27, sa.5, ss.657-660, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 5
- Basım Tarihi: 2014
- Doi Numarası: 10.20344/amp.5250
- Dergi Adı: Acta Medica Portuguesa
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.657-660
- Anahtar Kelimeler: CA-19-9 Antigen, Family, Tumor Markers, Biological
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Serum carbohydrate associated antigen (CA19-9) is widely used marker in clinical practice and shows small increases in a few benign diseases. Here we report two cases, a mother and her daughter with slightly elevated CA19-9 levels not accompanied by any clinical pathology. Case Presentation: The mother with elevated CA19-9 level (89.90 U/mL; upper limit of normal range (ULNR) < 37 U/mL) was referred to our department for evaluation. Similar increase was determined in her daughter incidentally. Daughter’s CA19-9 level was 123.92 U/mL. Extensive laboratory data, imaging procedures and clinical evaluations were within the normal ranges except elevated CA19- 9 levels for both. Also, any pathology compatible with the elevated CA19-9 level couldn’t be determined. In order to avoid laboratory errors and interferences, we measured the samples at four different immunoassay platforms twice. Conclusion: Healthy people can be in excess of the ULNR. Therefore, clinicians need to be aware of these rare situations without missing the malignant disorders.